Open AccessThe associations of incretin hormone concentration with gestational diabetes mellitus
Author(s) -
Т. В. Саприна,
Саприна Татьяна Владимировна,
Екатерина Сергеевна Тимохина,
Тимохина Екатерина Сергеевна,
Ольга Константиновна Гончаревич,
Гончаревич Ольга Константиновна,
Svetlana V. Budeeva,
Будеева Светлана Васильевна,
Т. С. Прохоренко,
Прохоренко Татьяна Сергеевна,
Л. А. Таширева,
Таширева Любовь Александровна,
Н. Н. Мусина,
Мусина Надежда Нурлановна,
Irina V. Dronova,
Дронова Ирина Владимировна
Publication year - 2016
Publication title -
saharnyj diabet
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.155
H-Index - 12
eISSN - 2072-0378
pISSN - 2072-0351
DOI - 10.14341/dm2004134-37
Subject(s) - incretin , medicine , postprandial , gestational diabetes , endocrinology , glucagon , basal (medicine) , hormone , pregnancy , diabetes mellitus , hyperinsulinemia , insulin resistance , type 2 diabetes , gestation , biology , genetics
Background: Enteropancreatic hormonal system disorder is a possible reason for β-cell dysfunction and carbohydrate metabolism disorder among pregnant women. However, no information is available about the state of enteroinsulin hormones [glucagon, glucose-dependent insulinotropic peptide (GIP), glucagon-like peptide1 (GLP-1) and GLP-2] during pregnancy. The role of enteroinsulin hormones in the development of carbohydrate metabolism disorder during pregnancy is poorly understood. Aim: To quantify and compare incretin hormone secretion in groups of pregnant women with and without gestational diabetes mellitus (GDM). Materials and methods: The study included 80 patients, 50 of whom had GDM, and the control group consisted of 30 pregnant women without GDM. All patients underwent an oral glucose tolerance test; glycated haemoglobin (HbA1c) estimation; ferritin, transferrin, basal and postprandial glucagon estimation; GLP-1 and GLP-2 estimation. Results: Basal glucagon and GLP-1 levels were significantly higher (p 0. 05) in the group of women with GDM than in the control group. The most significant differences in GLP-1, basal and postprandial glucagon levels were observed during the first trimester of pregnancy. Conclusion: High GLP-1 levels in the group of women with GDM may reflect a state of ‘incretin resistance’, which is similar to hyperinsulinemia in the early stages of type 2 diabetes mellitus.