Open AccessThe role of apoptosis in pathogenesis of type 1 diabetes mellitus
Author(s) -
Елена Владимировна Пекарева,
Tatiana Vasil'evikonova,
Olga Mikhailovna Smirnova
Publication year - 2010
Publication title -
saharnyj diabet
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.155
H-Index - 12
eISSN - 2072-0378
pISSN - 2072-0351
DOI - 10.14341/2072-0351-6016
Subject(s) - pathogenesis , apoptosis , medicine , diabetes mellitus , type 2 diabetes mellitus , immune system , beta cell , endocrinology , type 1 diabetes , immunology , cancer research , biology , biochemistry , islet
Type 1 diabetes mellitus (DM1) is known to be associated with progressive destruction of pancreatic beta-cells. Apoptosis plays the key role in this destructiveprocess. The paper focuses on major mechanisms underlying activation of beta-cell apoptosis and its role in regulation of immune processes inpatients with DM1.