Coagulation factors II,V and methylene tetrahydrofolate reductase gene polymorphism in patients with diabetic nephropathy: prevalence, clinical and prognostic implications | Zendy

О. Ф. Сибирева | Zendy; Ekaterina Yur'evna Khitrinskaya | Zendy; V. V. Kalyuzhin | Zendy; Aleksey Eduardovich Sazonov | Zendy; И. И. Иванчук | Zendy; Viktoriya Yur'evna Grankina | Zendy

Open Access

Coagulation factors II,V and methylene tetrahydrofolate reductase gene polymorphism in patients with diabetic nephropathy: prevalence, clinical and prognostic implications

Author(s) -

О. Ф. Сибирева,

Ekaterina Yur'evna Khitrinskaya,

V. V. Kalyuzhin,

Aleksey Eduardovich Sazonov,

И. И. Иванчук,

Viktoriya Yur'evna Grankina

Publication year - 2010

Publication title -

diabetes mellitus

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.155

H-Index - 12

eISSN - 2072-0378

pISSN - 2072-0351

DOI - 10.14341/2072-0351-6009

Subject(s) - methylenetetrahydrofolate reductase , medicine , gastroenterology , genotype , diabetic nephropathy , reductase , nephropathy , diabetes mellitus , gene mutation , point mutation , single nucleotide polymorphism , endocrinology , mutation , gene , genetics , kidney , enzyme , biology , biochemistry

Aim. To study prevalence, clinical and prognostic significance of prothrombotic genotypes pre-dominant in inborn thrombophilia in patients with diabeticnephropathy (DN). Materials and methods. A total of 90 patients with DN were examined; 54 and 36 cases suffered DM1 and DM2 respectively. Control group comprised100 healthy subjects. PCR was used to iden-tify single nucleotide substitution (C677T) in the methylene tetrahydrofolate reductase gene (MTHFR),point mutation in coagulation factor V gene (FV), and G202210A mutation in factor II gene (FII). Results. The probability of DN in patients with DM1 increases in the presence of Leiden mutation and in DM2 patients in the presence of single nucleotidesubstitu-tion (C677T) in MTHFR gene and G202210A mutation in the 3-untranslated region of FII. Conclusion. The prevalence of the above mutations associated with blood coagulation potential in DN patients is higher than in healthy subjects.Key words: diabetes mellitus, diabetic nephropathy, gene polymorphism, methylenetetrahydrofolate reductase

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