Open AccessThe role of coagulation and inflammation in the development of diabetic nephropathy in patients withdiabetes mellitus type 2
Author(s) -
Yuliya Valer'evna Khasanova,
А. А. Нелаева,
A B Galkina,
И. В. Медведева
Publication year - 2012
Publication title -
saharnyj diabet
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.155
H-Index - 12
eISSN - 2072-0378
pISSN - 2072-0351
DOI - 10.14341/2072-0351-5976
Subject(s) - medicine , diabetic nephropathy , fibrinogen , type 2 diabetes mellitus , inflammation , renal function , endocrinology , coagulation , nephropathy , diabetes mellitus , positive correlation
Aim. To reveal the role of inflammatory markers (homocystein (HC), interleukin-6 (IL-6)), components of hemostatic mechanism ofcoagulation in the development of diabetic nephropathy (DN) in patients with type 2 diabetes mellitus (T2DM). Materials and methods. A total of 240 patients with T2DM and DN were examined. Results. Negative correlation between HC level and glomerular filtration rate (GFR) (r= -0,38) and positive correlation between IL-6and fibrinogen (r=0,55) were observed. Conclusion. Inflammation and changes in mechanism of coagulation have influence on development and progression of DN in patientswith T2DM.