Open AccessFactors of tubulointerstitial lesions in diabetic kidneys
Author(s) -
Минара Шамхаловна Шамхалова,
Шамхалова Минара Шамхаловна,
Kseniya Olegovna Kurumova,
Курумова Ксения Олеговна,
Marina Shestakova,
Шестакова Марина Владимировна
Publication year - 2009
Publication title -
saharnyj diabet
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.155
H-Index - 12
eISSN - 2072-0378
pISSN - 2072-0351
DOI - 10.14341/2072-0351-5707
Subject(s) - medicine , nephrosclerosis , diabetic nephropathy , glomerulosclerosis , fibrosis , interstitial nephritis , nephropathy , pathology , nephritis , renal function , urology , diabetes mellitus , kidney , endocrinology , proteinuria
As the number of cases with classical manifestations of diabetic nephropathy (DN), i.e. nodular or diffuse glomerulosclerosis, grows, an increasinglylarger number of DM patients especially those with DM2 present with renal pathology largely affecting interstitium and tubules (ischemic nephropathy,urinary infection, interstitial nephritis, etc.). The rate of renal filtration impairment in glomerular diseases (DN, glomerulonephritis) is also relatedto the severity of tubulointerstitial fibrosis (TIF). Intricate intercellular interactions activated by immune and non-immune factors have been shownto play an important role in the development of tubulointerstitial lesions. Studies of the most important factors contributing to remodeling tubulointerstitiumin DM patients may provide a deeper insight into the mechanisms of nephrosclerosis and extend possibilities for prognostication of renalfunction.