Open AccessMetformin effects to carbohydrate and lipids metabolism in impaired glucose tolerance patients.
Author(s) -
Alexander Dreval,
Древаль Александр Васильевич,
И. В. Мисникова,
Мисникова Инна Владимировна,
И В Триголосова,
Триголосова Ирина Владимировна,
Р. С. Тишенина,
Тишенина Раиса Степановна
Publication year - 2010
Publication title -
saharnyj diabet
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.155
H-Index - 12
eISSN - 2072-0378
pISSN - 2072-0351
DOI - 10.14341/2072-0351-5676
Subject(s) - medicine , impaired glucose tolerance , metformin , endocrinology , carbohydrate metabolism , leptin , lipid metabolism , carbohydrate , metabolism , glucose tolerance test , glucose metabolism disorder , diabetes mellitus , type 2 diabetes , insulin resistance , obesity
Aim of this study was to investigate the effect metformin to carbohydrate, lipids metabolism and leptin level in impaired glucose tolerance (IGT)patients.Methods. 16 patients with IGT were studied. Age of participant was 55.1?8.2 yrs. All patients was divide into two groups: treatment group (bagomet1700 a day and diet) and control group (only diet). Effect of therapy was access in HbA1c, fasting glucose (FG), HOMA, lipids, liver glucose production(LGP) and leptin, which investigate in intravenous glucose tolerance test (IVGTT). Results. Normalization of carbohydrate metabolism was discover in 37.5% in treatment group and in 12.5% in control group. HbA1c was decreasefrom 6.4 to 5.9 % (р