Open AccessRenal functional reserve and tubular function in patents with type 2 diabetes mellitus
Author(s) -
Д. М. Хакимова,
Хакимова Диляра Махмутриевна,
А. Н. Максудова,
Максудова Аделя Наилевна,
И. Г. Салихов,
Салихов Ильдар Газимджанович
Publication year - 2011
Publication title -
saharnyj diabet
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.155
H-Index - 12
eISSN - 2072-0378
pISSN - 2072-0351
DOI - 10.14341/2072-0351-5641
Subject(s) - medicine , renal function , hemodynamics , endocrinology , diabetes mellitus , uric acid , type 2 diabetes mellitus , urine , excretion , urology
Aim. To study renal functional reserve and partial functions in patents with type 2 diabetes mellitus in the absence of renal lesionsMaterials and methods. We examined 42 patients (17 men and 24 women) aged 38-69 (mean 49.8?8.3) years with DM2 4.6?2.6 yr in duration.Control group comprised 32 practically healthy subjects. Intrarenal hemodynamics was estimated from RFR values. Ethanolamine, uric acid, Ca,and P levels were measured in sera and 24-hr urine; daily excretion of ammonia and aminonitrogen in the urine was determined. Results. The patients were divided into 2 groups based on the results of RFR measurement. FRF remained unaltered in 21 patients (mean 60.7?27.6%)and decreased in the absence of filtration reserve in 20 (-25.8?23.4%). Correlation analysis revealed the relationship of lipid metabolism and abdominalobesity with the renal tubular function and intraglomerular hemodynamics. Conclusion. Examination of DM2 patients without clinical and laboratory signs of renal lesions revealed compromised function of all nephron compartments,viz. intraglomerular hypertension, impaired stability of renal cell membranes, and tubular dysfunction. The latter is related to hemodynamic disturbances.