Open AccessAssociation of type 1 diabetes mellitus (DM1) with polymorphous alleles of class II HLA genes in Yakutian and Russian populations
Author(s) -
Е. В. Титович,
Титович Елена Витальевна,
Тамара Леонидовна Кураева,
Кураева Тамара Леонидовна,
Г И Данилова,
Г И Данилова,
Л П Алексеев,
Л П Алексеев,
М Н Болдырева,
М Н Болдырева,
А Н Никитин,
А Н Никитин,
О. Н. Иванова,
О.Н. Иванова,
S A Prokofiev,
Прокофьев Сергей Александрович,
L. I. Zilberman,
Зильберман Любовь Иосифовна,
N M Tsitlidze,
Н М Цитлидзе,
В. В. Носиков,
Носиков Валерий Вячеславович,
И И Дедов,
Дедов Иван Иванович
Publication year - 2009
Publication title -
saharnyj diabet
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.155
H-Index - 12
eISSN - 2072-0378
pISSN - 2072-0351
DOI - 10.14341/2072-0351-5448
Subject(s) - allele , genotyping , human leukocyte antigen , population , medicine , genetics , biology , genotype , gene , immunology , antigen , environmental health
Materials and methods. HLA genotyping was accomplished in 51 DM1 patients and 51 volunteers randomly selected from the indigenous populationof Yakutia (Yakuts in three successive generations). Another 205 DM1 patients and 300 healthy subjects comprised random samples of patients andcontrols respectively from residents of Moscow and Moscow region. Results. HLA DRB1*17(03) allele proved to be the strongest one predisposing to DM1 in the Yakutian population (relative risk, RR=8,47) andDQB1*0304 in the Moscow population (RR=8,94). The presence of DRB1*04, DRB1*17(03), DQA1*0301, DQB1*0201, and DQB1*0302 accountedfor RR >2 in both populations. Only two alleles, DRB1*04 and DRB17(03), in the Yakutian population and five of the six (DRB1*04,DRB1*17(03), DQA1*(0301), DQB1*0302, and DQB1*0304) in the Moscow one were closely associated with DM1 (RR >4). DRB1*09, DRB1*11,DQB1*13, DQB1*0602/8 in Yakutian and DRB1*11, DRB1*13, DQA1*0103, DQB1*0301, DQB1*0602/8 in Moscow populations had the highestprotective potential (RR