Association of type 1 diabetes mellitus (DM1) with polymorphous alleles of class II HLA genes in Yakutian and Russian populations | Zendy

Елена Витальевна Титович | Zendy; Тамара Леонидовна Кураева | Zendy; G I Danilova | Zendy; L P Alekseev | Zendy; M N Boldyreva | Zendy; A N Nikitin | Zendy; О Н Иванова | Zendy; Sergey Alexandrovich Prokofiev | Zendy; L. I. Zilberman | Zendy; N M Tsitlidze | Zendy; В. В. Носиков | Zendy; Ivan Ivanovich Dedov | Zendy

Open Access

Association of type 1 diabetes mellitus (DM1) with polymorphous alleles of class II HLA genes in Yakutian and Russian populations

Author(s) -

Елена Витальевна Титович,

Тамара Леонидовна Кураева,

G I Danilova,

L P Alekseev,

M N Boldyreva,

A N Nikitin,

О Н Иванова,

Sergey Alexandrovich Prokofiev,

L. I. Zilberman,

N M Tsitlidze,

В. В. Носиков,

Ivan Ivanovich Dedov

Publication year - 2009

Publication title -

diabetes mellitus

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.155

H-Index - 12

eISSN - 2072-0378

pISSN - 2072-0351

DOI - 10.14341/2072-0351-5448

Subject(s) - allele , genotyping , human leukocyte antigen , population , medicine , genetics , biology , genotype , gene , immunology , antigen , environmental health

Materials and methods. HLA genotyping was accomplished in 51 DM1 patients and 51 volunteers randomly selected from the indigenous populationof Yakutia (Yakuts in three successive generations). Another 205 DM1 patients and 300 healthy subjects comprised random samples of patients andcontrols respectively from residents of Moscow and Moscow region. Results. HLA DRB1*17(03) allele proved to be the strongest one predisposing to DM1 in the Yakutian population (relative risk, RR=8,47) andDQB1*0304 in the Moscow population (RR=8,94). The presence of DRB1*04, DRB1*17(03), DQA1*0301, DQB1*0201, and DQB1*0302 accountedfor RR >2 in both populations. Only two alleles, DRB1*04 and DRB17(03), in the Yakutian population and five of the six (DRB1*04,DRB1*17(03), DQA1*(0301), DQB1*0302, and DQB1*0304) in the Moscow one were closely associated with DM1 (RR >4). DRB1*09, DRB1*11,DQB1*13, DQB1*0602/8 in Yakutian and DRB1*11, DRB1*13, DQA1*0103, DQB1*0301, DQB1*0602/8 in Moscow populations had the highestprotective potential (RR

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