Open AccessThe system of osteoprotegrin (OPG)/ligand of NF-kB receptor activator (RANKL) in patients with diabetes mellitus, mediacalcinosis and obliteratingatherosclerosis of lower leg arteries
Author(s) -
Марианна Viktorovna Yaroslavtseva,
Ярославцева Марианна Викторовна,
Iriikolaevna Ul'yanova,
Ульянова Ирина Николаевна,
Gagik Radikovich Galstyan,
Галстян Гагик Радикович,
А. В. Ильин,
А. В. Ильин,
Larisa Nikankina,
Larisa Nikankina,
О. В. Ремизов,
Ремизов Олег Валерьевич,
И И Дедов,
Дедов Иван Иванович
Publication year - 2009
Publication title -
saharnyj diabet
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.155
H-Index - 12
eISSN - 2072-0378
pISSN - 2072-0351
DOI - 10.14341/2072-0351-5416
Subject(s) - medicine , osteoprotegerin , rankl , diabetes mellitus , type 2 diabetes mellitus , bone remodeling , endocrinology , bone mineral , osteoporosis , cardiology , receptor , activator (genetics)
Aim. To study the OPG/RANKL system in patients with diabetes mellitus, mediacalcinosis and obliterating atherosclerosis of lower leg arteries. Materials and methods. The study enrolled 70 patients including 20 with manifest diabetic neuropathy (DN) and mediacalcinosis of lower leg arteries(group 1). 29 patients with diabetes mellitus (DM) and clinical manifestations of obliterating atherosclerosis of lower leg arteries comprised group 2. Thecontrol group 3 consisted of 30 subjects without disturbances of carbohydrate metabolism. Immunoassays with Alkphase-B (Metra biosystems, USA),Osteoprotegrin (Biomedica, Austria), and sRANKL(Biomedica, Austria) kits were used to detect serum markers of bone formation (alkaline phosphatase(AP), OPG, and RANKL respectively). The patients underwent examination by digital X-ray of affected joints in frontal and lateral projections using anAxiom Iconos R 200 apparatus (Siemens, Germany). Bone mineral density (BMD) was measured by dual energy X-ray absorptiometry (Expert 1188,Lunar, USA). Ultrasound duplex scanning of lower leg arteries was performed with Sonoc-5500 (Agilent, USA). Results. OPG levels in diabetic patients were significantly higher than in controls (p