Open AccessAbnormal Na-K-ATPase activity in erythrocytes from patients with diabetes mellitus
Author(s) -
Zulaykho Shamansurova,
Zulaykho Shamansurova,
Ф А Мухамедова,
Ф А Мухамедова,
А Г Цой,
Цой А Г,
Akmaral Tashmanova,
Akmaral Tashmanova,
Anna Alieva,
А В Алиева,
Nilufar Akhrarova,
Nilufar Akhrarova
Publication year - 2009
Publication title -
saharnyj diabet
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.155
H-Index - 12
eISSN - 2072-0378
pISSN - 2072-0351
DOI - 10.14341/2072-0351-5399
Subject(s) - diabetes mellitus , medicine , endocrinology , atpase , nitrite , biochemistry , enzyme , chemistry , nitrate , organic chemistry
Aim. To measure Na-K-ATPase activity in erythrocytes from patients with diabetes mellitus (DM), elucidate its relationship with clinical manifestationsof the disease and biochemical blood characteristics. Materials and methods. A total of 76 DM patients were enrolled in this study (39 with DM1 and 35 with DM2). Control group consisted of 11 subjectswithout DM. They were examined for HbA1c, nitrite and nitrate levels in blood and membranes, sialidase activity in erythrocytes and Na-KATPaseactivity measured from variations of inorganic phosphorus content in the presence of ATP. Results. Na-K-ATPase activity in MD patients was significantly lower than in controls (p