Open AccessEffect of chronic hyperglycaemia on the parameters of protein, lipid metabolism and platelet-coagulation haemostasis in acromegaly
Author(s) -
Г. Г. Петрик,
С. А. Павлищук
Publication year - 2011
Publication title -
ožirenie i metabolizm
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.154
H-Index - 5
eISSN - 2306-5524
pISSN - 2071-8713
DOI - 10.14341/2071-8713-5299
Subject(s) - acromegaly , medicine , platelet , diabetes mellitus , dyslipidemia , fibrinogen , endocrinology , hemostasis , coagulation , mean platelet volume , cholesterol , hormone , growth hormone
The aim of the research. Assessing the impact of chronic hyperglycemia on the parameters of the protein, lipid metabolismand platelet-coagulation haemostasis in patients with active phase of acromegaly. Materials and methods: The research included 58 patientswith the active phase of acromegaly (36 women and 28 men), median age 50 (43, 57) years, disease duration 9.0 (5.0, 15.0) years,26 of whom had verified diabetes mellitus. Results: Biochemical parameters and parameters of haemostasis in patients with activephase of acromegaly with normoglycemia differed from the control group by higher levels of total cholesterol, high-density lipoproteins,an increase in the average volume of platelet aggregation and enhancement of their function. The presence of diabetes mellituswas accompanied by the increase in concentration of total cholesterol, triglycerides, decrease in high-density lipoproteins, and increasein fibrinogen concentration, soluble fibrin-monomeasured complexes, as well as reduction of disaggregation properties of plateletsand enhancement of ejection reactions. Conclusion: The presence of diabetes mellitus with acromegaly can be regarded as a significantrisk factor for atherogenic dyslipidemia, hyperfibrinogenemia and platelet disfunction.