Open AccessAktivnost' renin-angiotenzinovoy sistemy (RAS) zhirovoy tkani: metabolicheskie effekty blokady RAS
Author(s) -
М. В. Шестакова
Publication year - 2011
Publication title -
ožirenie i metabolizm
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.154
H-Index - 5
eISSN - 2306-5524
pISSN - 2071-8713
DOI - 10.14341/2071-8713-5187
Subject(s) - endocrinology , medicine , aliskiren , autocrine signalling , renin–angiotensin system , insulin resistance , paracrine signalling , metabolic syndrome , type 2 diabetes mellitus , obesity , adipose tissue , angiotensin converting enzyme , type 2 diabetes , diabetes mellitus , receptor , biology , blood pressure
The review presents data confirming that fat tissue is a significant source of synthesis of all components of renin-angiotensinsystem (RAS). It is proposed that activation of fat tissue RAS components have a local paracrine and autocrine actions on adipocytes,regulates their growth and differentiation, induces subclinical inflammation and insulin resistance (IR). Thus, hyperactivity of localRAS in fat tissue is one of the mechanisms of visceral obesity, IR and metabolic syndrome. Use of traditional RAS blocking medications(angiotensin converting enzyme inhibitors, angiotensin receptor blockers) is followed by IR decrease and prevents from development oftype 2 diabetes mellitus. The perspectives of use of a new RAS blocker from a group of direct rennin inhibitors - aliskiren - for correctionof metabolic abnormalities in visceral obesity are considered.