Open AccessClinical case: multiple endocrine neoplasia type 1 (MEN 1)
Author(s) -
A K Lipatenkova,
Л. К. Дзеранова,
Е А Пигарова,
L Ya Rozhinskaya,
А. В. Кочатков
Publication year - 2012
Publication title -
ožirenie i metabolizm
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.154
H-Index - 5
eISSN - 2306-5524
pISSN - 2071-8713
DOI - 10.14341/2071-8713-5129
Subject(s) - endocrine system , multiple endocrine neoplasia , men1 , pancreas , endocrinology , medicine , endocrine gland , biology , hormone , genetics , gene
Multiple endocrine neoplasia syndrome type 1 (MEN1, Wermer syndrome) – group o а heterogeneous inherited deseases, caused by hyperlasia or neoplasia of several endocrine glands. The phenotype of MEN1 is broad, and over 20 different combinations of endocrine and non-endocrine metabolic manifestations have been described. This case demonstrates multiple formations of endocrine organs, starting non-classical with macroprolactonoma resistant to dopamine agonists therapy, other endocrine disorders developed gradually eventually: hyperparathyreoidism and hypoglycemia caused by pancreas lesions, produced proinsulin in high levels.