Open AccessDinamika indeksa massy miokarda levogozheludochka u patsientov s arterial'noygipertoniey II-III stepeni na fone terapiiKo-renitekom i Gizaarom
Author(s) -
A. A. Kudryavtsev,
A S Ryazanov,
Н. Н. Еременко,
С. А. Киреев
Publication year - 2010
Publication title -
ožirenie i metabolizm
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.154
H-Index - 5
eISSN - 2306-5524
pISSN - 2071-8713
DOI - 10.14341/2071-8713-5086
Subject(s) - enalapril , losartan , cardiology , medicine , thiazide , muscle hypertrophy , diuretic , blood pressure , angiotensin ii , angiotensin converting enzyme
The regress or left ventricular (LV) hypertrophy is a main end-point of antihypertensive therapy. The aim of the present studywas to compare antihypertensive effects of two fixed combination preparations of ACE inhibitor and thiazide diuretic, enalapril 20 mg/hydrochlorthiazide12,5 mg (Co-renitec) and losartan 50 mg/hydrochlorthiazide 12,5 mg (Hyzaar) on LV mass index (LVMI), types of leftventricular remodeling in patients with grade II-III arterial hypertension. First group was treated with Co-renitec, second group withHyzaar during 24-weeks period. Results showed that both preparations significantly and to the same degree decrease LVMI. Number ofpatients with normal LV geometry increases with accompanying decrease in number of patients with concentric hypertrophy and concentricremodeling. The favorable effects were more remarkable in group treated with Hyzaar.