Kriteriy diagnostiki dosimptomaticheskoy(premorbidnoy) stadii metabolicheskogo sindroma

It is well known that metabolic syndrome (MS) substantially increases the risk of the development of cardiovascular disease,type 2 diabetes and associated mortality. This makes the search of markers of predisposition to MS and predictors of visceral involvementin people with normal body mass an extremely pressing problem, as it is the basis of early prophylaxis. The aim of the researchwas to determine the early (premorbid) markers of MS. Patients: 458 practically healthy young people aged 18-25. Methods: anthropometricparameters (body mass index, waist circumference), fat component in body composition (FCBC) «BF-306 OMRON»(Japan), lipid (Triglyceride, Total Cholesterol, LDL-Cholesterol, LHL-Cholesterol) and glucose metabolism parameters (Glucose,Immunoreactive insulin, C-peptide, Insulin resistance index HOMA-IR). Results. We found a close correlation of FCBC with glucose(r=0,564-0,427; p=0,01-0,04) and lipid (r=0,547-0,734; p=0,001-0,04) metabolic parameters inherent to MS in young people withnormal body mass, which made it possible to consider FCBC as a marker premorbidity of MS (sensitivity - 100%, specificity - 96%).Herein we present an algorithm of diagnostic and tactic activities, which can be used in patients of high risk group for developmentof MS, including measures of early prophylaxis and preventive therapy.