Open AccessRasprostranennost' narusheniy svertyvayushchey i protivosvertyvayushchey sistem krovi u zhenshchin s metabolicheskim sindromom v postmenopauze
Author(s) -
M A Berkovskaya,
С А Бутрова
Publication year - 2010
Publication title -
ožirenie i metabolizm
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.154
H-Index - 5
eISSN - 2306-5524
pISSN - 2071-8713
DOI - 10.14341/2071-8713-4979
Subject(s) - fibrinogen , medicine , prothrombin time , factor vii , metabolic syndrome , partial thromboplastin time , lupus anticoagulant , endocrinology , antithrombin , protein c , anticoagulant , thrombophilia , protein s , coagulation , thrombosis , obesity , heparin
The object of the study was to assess the prevalence of prothrombotic alterations in coagulant and anticoagulant systems amongpostmenopausal women with metabolic syndrome and to determine the associations between these abnormalities and main anthropometricmeasures and parameters of glucose and lipid metabolism. Cross-sectional observational study included 55 postmenopausal women(age 45-65) with metabolic syndrome. Coagulant system was assessed by measurement of parameters of plasma haemostasis (prothrombinindex, Activated Partial Thromboplastin Time (APTT), thrombin time, fibrinogen concentration), and the activities of coagulant factorsVII (FVII) and VIII (FVIII) in plasma. In order to investigate the functioning of anticoagulant system the activities of antithrombin IIIand anticoagulant system of protein C were measured. Prothrombotic alterations were observed in 81,5% women. The APTT was decreasedin 14,5%, hyperfibrinogenemia was revealed in 42,6%, the increased activity of FVII - in 50,9%, and the decreased activityof protein C system - in 23,9%. There were a significant positive associations between some of revealed prothrombotic alterations andanthropometric and biochemical markers of visceral obesity and metabolic syndrome (parameters of glucose and lipid metabolism).There were no any associations between haemostatic indices and age. In conclusion, there is an evidence of high prevalence of differentprothrombotic alterations in coagulant and anticoagulant systems among postmenopausal women with metabolic syndrome. Metabolicsyndrome in postmenopause is associated with the development of prothrombotic state independently of age.