Open AccessVliyanie metformina na provospalitel'nyei prokoagulyantnye narusheniya u patsientokv postmenopauze s metabolicheskim sindromom
Author(s) -
M A Berkovskaya,
С А Бутрова,
В. В. Фадеев
Publication year - 2011
Publication title -
ožirenie i metabolizm
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.154
H-Index - 5
eISSN - 2306-5524
pISSN - 2071-8713
DOI - 10.14341/2071-8713-4951
Subject(s) - medicine , fibrinogen , metformin , plasminogen activator , antithrombin , tissue factor pathway inhibitor , adiponectin , gastroenterology , c reactive protein , partial thromboplastin time , von willebrand factor , thrombin time , prothrombin time , endocrinology , coagulation , insulin resistance , insulin , heparin , platelet , inflammation , tissue factor
The aim of the study was to assess the effect of metformin plus lifestyle modification on procoagulant and proinflammatory stateassociated with metabolic syndrome in postmenopausal women. Materials and methods: The 12-month prospective, open, randomizedstudy included 58 postmenopausal women (age 55 [53; 56]; postmenopause 5 [4; 8] years) with metabolic syndrome (IDF, 2005).Participants were randomized into two groups receiving either metformin (1 g per day) plus lifestyle modification (n=29), or lifestylemodification alone (control group) (n=29). Blood tests were performed before and after the treatment period to evaluate parametersof coagulant and anticoagulant blood systems: prothrombin index, activated partial tromboplastin time (APTT), thrombin time, activitiesof factors VII (FVII),VIII (FVIII), von Willebrand factor (vWF), antithrombin III, plasminogen activator inhibitor-1 (PAI-1),tissue-type plasminogen activator (t-PA) and screening test for the protein C pathway. Also we assessed fibrinogen, C-reactive protein(CRP) and adiponectin concentrations. Results: After one year of treatment in metformin group CRP level decreased significantlyfrom 4,98 [2,72; 11,95] to 2,56 [1,92; 6,76] mg/l (р