Open AccessMekhanizmy narusheniya obmena glyukozy u litss «prediabetom»
Author(s) -
A. V. Dreval,
И. В. Мисникова,
И В Триголосова,
И А Барсуков
Publication year - 2009
Publication title -
ožirenie i metabolizm
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.154
H-Index - 5
eISSN - 2306-5524
pISSN - 2071-8713
DOI - 10.14341/2071-8713-4874
Subject(s) - medicine , impaired glucose tolerance , endocrinology , insulin resistance , impaired fasting glucose , diabetes mellitus , type 2 diabetes mellitus , insulin , hemoglobin
We have performed an estimation of metabolic disorders in 70 persons with various early glucose metabolism abnormalities(IFG and IGT). Oral glucose tolerance test (ОGTT) and intravenous glucose tolerance test (IVGTT) were done in all subjects. HbA1с,insulin and C-peptide levels were also determined. Further НОМА-R, QUICKI, MATSUDA indexes, speed of glucose elimination fromthe blood (k), production of glucose (H) and a degree of glucose metabolism disorders (pN) were estimated. Glucose hyperproductionand liver insulin resistance is more typical for IFG, than for isolated IGT. It was confirmed by higher parameter of liver glucose production(H) and HOMA-R index in patients with IFG. On the contrary peripheral insulin resistance is more typical for isolated IGT. Index of insulinsensitivity MATSUDA and speed of glucose elimination from the blood (k) were lower in IGT than in IFG patients. First phaseof insulin secretion was broken in patients with combination IGT and IFG, which can explain the high incidence of transformation in2 type diabetes mellitus in patients with combination IGT and IFG. The lowest HbA1c levels was found among persons with IGT. It islikely that ordinary life food intake (not glucose loading) in this group of patients does not result in chronic hyperglycemia and excessivehemoglobin glycation.