Open AccessIntestinal Flora: A Potential New Regulator of Cardiovascular Disease
Author(s) -
Yifei Zou,
Xianjing Song,
Ning Liu,
Weiyi Sun,
Bin Liu
Publication year - 2022
Publication title -
aging and disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.808
H-Index - 54
ISSN - 2152-5250
DOI - 10.14336/ad.2021.1022
Subject(s) - flora (microbiology) , disease , medicine , intensive care medicine , gut flora , regulator , biology , immunology , bacteria , biochemistry , genetics , gene
Although substantial progress has been made in reducing the burden of the disease by preventing the risk factors of cardiovascular disease (CVD), potential risk factors still exist and lead to its progression. In recent years, numerous studies have revealed that intestinal flora can interfere with the physiological processes of the host through changes in composition and function or related metabolites. Intestinal flora thus affects the occurrence and development of a variety of CVDs, including atherosclerosis, ischemic heart disease, and heart failure. Moreover, studies have found that interventions for intestinal flora and its metabolites provide new opportunities for CVD treatment. This article mainly discusses the interaction between the human intestinal flora and its metabolites, the occurrence and development of CVD, and the potential of intestinal flora as a new target for the diagnosis and treatment of CVD.