Open AccessPotential Crosstalk Between Parkinson's Disease and Energy Metabolism
Author(s) -
Meiqiu Liu,
Qian Jiang,
Xixun Du,
Minghong Bi,
Xi Chen,
Hong Jiang
Publication year - 2021
Publication title -
aging and disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.808
H-Index - 54
ISSN - 2152-5250
DOI - 10.14336/ad.2021.0422
Subject(s) - substantia nigra , parkinson's disease , dorsal motor nucleus , dopaminergic , crosstalk , lipid metabolism , neuroscience , central nervous system , metabolism , medicine , energy metabolism , pars compacta , gastrointestinal tract , disease , endocrinology , biology , dopamine , vagus nerve , physics , optics , stimulation
Parkinson's disease (PD) is characterized by the accumulation of alpha-synuclein (α-Syn) in the substantia nigra (SN) and the degeneration of nigrostriatal dopaminergic (DAergic) neurons. Some studies have reported that the pathology of PD originates from the gastrointestinal (GI) tract, which also serves as an energy portal, and develops upward along the neural pathway to the central nervous system (CNS), including the dorsal motor nucleus of vagus (DMV), SN, and hypothalamus, which are also involved in energy metabolism control. Therefore, we discuss the alterations of nuclei that regulate energy metabolism in the development of PD. In addition, due to their anti-inflammatory, antiapoptotic and antioxidative roles, metabolism-related peptides are involved in the progression of PD. Furthermore, abnormal glucose and lipid metabolism are common in PD patients and exacerbate the pathological changes in PD. Therefore, in this review, we attempt to explain the correlation between PD and energy metabolism, which may provide possible strategies for PD treatment.