Open AccessNeuroplastic Effect of Exercise Through Astrocytes Activation and Cellular Crosstalk
Author(s) -
Fengwu Li,
Geng Xu,
Ho Jun Yun,
Yazeed Haddad,
Yuhua Chen,
Yuchuan Ding
Publication year - 2021
Publication title -
aging and disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.808
H-Index - 54
ISSN - 2152-5250
DOI - 10.14336/ad.2021.0325
Subject(s) - neuroplasticity , neurogenesis , microglia , neuroscience , crosstalk , astrocyte , neurorehabilitation , neurite , medicine , biology , central nervous system , inflammation , rehabilitation , physics , optics , biochemistry , in vitro
Physical exercise is an effective therapy for neurorehabilitation. Exercise has been shown to induce remodeling and proliferation of astrocyte. Astrocytes potentially affect the recruitment and function of neurons; they could intensify responses of neurons and bring more neurons for the process of neuroplasticity. Interactions between astrocytes, microglia and neurons modulate neuroplasticity and, subsequently, neural circuit function. These cellular interactions promote the number and function of synapses, neurogenesis, and cerebrovascular remodeling. However, the roles and crosstalk of astrocytes with neurons and microglia and any subsequent neuroplastic effects have not been studied extensively in exercise-induced settings. This article discusses the impact of physical exercise on astrocyte proliferation and highlights the interplay between astrocytes, microglia and neurons. The crosstalk between these cells may enhance neuroplasticity, leading to the neuroplastic effects of exercise.