Open AccessCOVID-19 and Senotherapeutics: Any Role for the Naturally-occurring Dipeptide Carnosine?
Author(s) -
Alan R. Hipkiss
Publication year - 2020
Publication title -
aging and disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.808
H-Index - 54
ISSN - 2152-5250
DOI - 10.14336/ad.2020.0518
Subject(s) - carnosine , dipeptide , covid-19 , peptide , medicine , apelin , pharmacology , histidine , virology , chemistry , biochemistry , enzyme , receptor , outbreak , disease , infectious disease (medical specialty)
It is suggested that the non-toxic dipeptide carnosine (beta-alanyl-L-histidine) should be examined as a potential protective agent against COVID-19 infection and inflammatory consequences especially in the elderly. Carnosine is an effective anti-inflammatory agent which can also inhibit CD26 and ACE2 activity. It is also suggested that nasal administration would direct the peptide directly to the lungs and escape the attention of serum carnosinase.