Open AccessSerine and Metabolism Regulation: A Novel Mechanism in Antitumor Immunity and Senescence
Author(s) -
Qi Wu,
Xinyue Chen,
Juanjuan Li,
Shengrong Sun
Publication year - 2020
Publication title -
aging and disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.808
H-Index - 54
ISSN - 2152-5250
DOI - 10.14336/ad.2020.0314
Subject(s) - serine , immune system , anabolism , immunity , mechanism (biology) , metabolism , senescence , catabolism , biology , epigenetics , microbiology and biotechnology , biochemistry , immunology , phosphorylation , gene , philosophy , epistemology
As one of the nonessential amino acids (NEAAs), serine is involved in the anabolism of multiple macromolecular substances by participating in one-carbon unit metabolism. Thus, rapidly proliferating cells such as tumor cells and activated immune cells are highly dependent on serine. Serine supports the proliferation of various immune cells through multiple pathways to enhance the antitumor immune response. Moreover, serine influences aging specificity in an epigenetic and metabolic manner. In this review, we focus on recent advances in the relationship between serine metabolism, antitumor immunity, and senescence. The metabolic regulation of serine seems to be a key point of intervention in antitumor immunity and aging-related disease, providing an opportunity for several novel therapeutics.