Open AccessInfrapatellar Fat Pad and Knee Osteoarthritis
Author(s) -
Ni Zeng,
Zhi-Peng Yan,
Xinyuan Chen,
GuoXin Ni
Publication year - 2020
Publication title -
aging and disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.808
H-Index - 54
ISSN - 2152-5250
DOI - 10.14336/ad.2019.1116
Subject(s) - infrapatellar fat pad , osteoarthritis , medicine , fat pad , adipose tissue , narrative review , cartilage , disease , bioinformatics , arthritis , pathology , intensive care medicine , anatomy , alternative medicine , biology
Osteoarthritis is the most prevalent arthritis typically characterized by degradation of cartilage. However, its pathogenesis is not fully understood. Currently, osteoarthritis is best considered a disease of the whole "joint organ". Infrapatellar fat pad (IFP), an adipose tissue near synovium, is now attaching importance to researchers for its inflammatory phenotype. In this narrative review, a large body of evidence has been gathered for the involvement of IFP in the development of knee osteoarthritis. Additionally, the underlying mechanisms of how IFP can be involved in this process have been proposed. However, further investigations are needed to better understand its precise role in this process and its underlying mechanism, and beyond that, to develop new strategies to slow down the degenerative process and explore an effective and timely diagnosis of the disease.