Open AccessCaveolin as a Novel Potential Therapeutic Target in Cardiac and Vascular Diseases: A Mini Review
Author(s) -
Jinfan Tian,
Mohammad Sharif Popal,
Rongchong Huang,
Min Zhang,
Xin Zhao,
Mingduo Zhang,
Xiantao Song
Publication year - 2020
Publication title -
aging and disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.808
H-Index - 54
ISSN - 2152-5250
DOI - 10.14336/ad.2019.09603
Subject(s) - caveolae , crosstalk , caveolin 1 , autophagy , signal transduction , caveolin , oxidative stress , microbiology and biotechnology , biogenesis , nitric oxide , homeostasis , medicine , function (biology) , neuroscience , bioinformatics , biology , biochemistry , apoptosis , physics , gene , optics
Caveolin, a structural protein of caveolae, play roles in the regulation of endothelial function, cellular lipid homeostasis, and cardiac function by affecting the activity and biogenesis of nitric oxide, and by modulating signal transduction pathways that mediate inflammatory responses and oxidative stress. In this review, we present the role of caveolin in cardiac and vascular diseases and the relevant signaling pathways involved. Furthermore, we discuss a novel therapeutic perspective comprising crosstalk between caveolin and autophagy.