Open AccessInterplay between Exosomes and Autophagy in Cardiovascular Diseases: Novel Promising Target for Diagnostic and Therapeutic Application
Author(s) -
Jinfan Tian,
Mohammad Sharif Popal,
Yingke Zhao,
Yanfei Liu,
Keji Chen,
Yue Liu
Publication year - 2019
Publication title -
aging and disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.808
H-Index - 54
ISSN - 2152-5250
DOI - 10.14336/ad.2018.1020
Subject(s) - autophagy , microvesicles , context (archaeology) , exosome , nanocarriers , homeostasis , microbiology and biotechnology , biology , disease , medicine , bioinformatics , computational biology , microrna , pharmacology , pathology , drug , genetics , apoptosis , paleontology , gene
Exosome, is identified as a nature nanocarrier and intercellular messenger that regulates cell to cell communication. Autophagy is critical in maintenance of protein homeostasis by degradation of damaged proteins and organelles. Autophagy and exosomes take pivotal roles in cellular homeostasis and cardiovascular disease. Currently, the coordinated mechanisms for exosomes and autophagy in the maintenance of cellular fitness are now garnering much attention. In the present review, we discussed the interplay of exosomes and autophagy in the context of physiology and pathology of the heart, which might provide novel insights for diagnostic and therapeutic application of cardiovascular diseases.