Open AccessSnapshot: Implications for mTOR in Aging-related Ischemia/Reperfusion Injury
Author(s) -
Dong Liu,
Liqun Xu,
Xiaoyan Zhang,
Changhong Shi,
Shubin Qiao,
Zhiqiang Ma,
Jiansong Yuan
Publication year - 2019
Publication title -
aging and disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.808
H-Index - 54
ISSN - 2152-5250
DOI - 10.14336/ad.2018.0501
Subject(s) - pi3k/akt/mtor pathway , autophagy , medicine , mtorc2 , kinase , discovery and development of mtor inhibitors , reperfusion injury , sirolimus , ischemia , bioinformatics , signal transduction , biology , microbiology and biotechnology , mtorc1 , apoptosis , biochemistry
Aging may aggravate the damage and dysfunction of different components of multiorgan and thus increasing multiorgan ischemia/reperfusion (IR) injury. IR injury occurs in many organs and tissues, which is a major cause of morbidity and mortality worldwide. The kinase mammalian target of rapamycin (mTOR), an atypical serine/threonine protein kinase, involves in the pathophysiological process of IR injury. In this review, we first briefly introduce the molecular features of mTOR, the association between mTOR and aging, and especially its role on autophagy. Special focus is placed on the roles of mTOR during ischemic and IR injury. We then clarify the association between mTOR and conditioning phenomena. Following this background, we expand our discussion to potential future directions of research in this area. Collectively, information reviewed herein will serve as a comprehensive reference for the actions of mTOR in IR injury and may be significant for the design of future research and increase the potential of mTOR as a therapeutic target.