Elevated Inflammatory Status and Increased Risk of Chronic Disease in Chronological Aging: Inflamm-aging or Inflamm-inactivity? | Zendy

Michael G. Flynn | Zendy; Melissa M. Markofski | Zendy; Andres E. Carrillo | Zendy

Open Access

Elevated Inflammatory Status and Increased Risk of Chronic Disease in Chronological Aging: Inflamm-aging or Inflamm-inactivity?

Author(s) -

Michael G. Flynn,

Melissa M. Markofski,

Andres E. Carrillo

Publication year - 2018

Publication title -

aging and disease

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.808

H-Index - 54

ISSN - 2152-5250

DOI - 10.14336/ad.2018.0326

Subject(s) - medicine , disease , inflammation , healthy aging , gerontology , immunology

Age-associated hyper-inflammation or "inflamm-aging" has been linked to the development of chronic diseases and characterized as an unavoidable aspect of aging. However, the inflamm-aging model does not adequately address the potential anti-inflammatory effects of exercise training and the potential for exercise to ameliorate several age-related diseases. In this brief review, we introduce a new paradigm- inflamm-inactivity -that describes a potent counter-measure to age-associated inflammatory illness.

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