Open AccessElevated Inflammatory Status and Increased Risk of Chronic Disease in Chronological Aging: Inflamm-aging or Inflamm-inactivity?
Author(s) -
Michael G. Flynn,
Melissa M. Markofski,
Andres E. Carrillo
Publication year - 2019
Publication title -
aging and disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.808
H-Index - 54
ISSN - 2152-5250
DOI - 10.14336/ad.2018.0326
Subject(s) - medicine , disease , inflammation , healthy aging , gerontology , immunology
Age-associated hyper-inflammation or "inflamm-aging" has been linked to the development of chronic diseases and characterized as an unavoidable aspect of aging. However, the inflamm-aging model does not adequately address the potential anti-inflammatory effects of exercise training and the potential for exercise to ameliorate several age-related diseases. In this brief review, we introduce a new paradigm- inflamm-inactivity -that describes a potent counter-measure to age-associated inflammatory illness.