Open AccessRelationship between Hypothyroidism and Endometrial Cancer
Author(s) -
Yiqin Wang,
Rong Zhou,
Jianliu Wang
Publication year - 2019
Publication title -
aging and disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.808
H-Index - 54
ISSN - 2152-5250
DOI - 10.14336/ad.2018.0224
Subject(s) - endometrial cancer , medicine , infertility , endometrium , cancer , ovarian cancer , oncology , thyroid cancer , gynecology , carcinoma , pregnancy , biology , genetics
Thyroid dysfunction is involved in several types of carcinoma. Hypothyroidism is one of the most common medical morbidities among patients with endometrial cancer; however, the related mechanism is unclear. Among the risk factors related to endometrial cancer, hypothyroidism interacts with metabolic syndrome, polycystic ovarian syndrome and infertility or directly acts on the endometrium itself, which may influence the development and progression of endometrial cancer. We summarize recent studies on the relationship between hypothyroidism and endometrial cancer and its risk factors to provide references for basic research as well as for clinical treatment and prognostic evaluation.