Open AccessSearching for Factors Raising the Incidence of Metabolic Syndrome Among 45-60-Year-Old Women
Author(s) -
Małgorzata Szkup,
Jacek Brodowski,
Aleksander Owczarek,
Piotr Choręża,
Anna Jurczak,
Elżbieta Grochans
Publication year - 2018
Publication title -
aging and disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.808
H-Index - 54
ISSN - 2152-5250
DOI - 10.14336/ad.2017.1027
Subject(s) - metabolic syndrome , medicine , incidence (geometry) , anthropometry , obesity , allele , population , insulin resistance , family history , fto gene , genotype , allele frequency , endocrinology , polymorphism (computer science) , physiology , genetics , gene , biology , environmental health , physics , optics
Metabolic syndrome is an increasing health problem, whose pathogenesis may be associated with genetic factors. The main purpose of our study was to assess relationships between MetS and the presence of the FTO rs9939609, the MC4R rs17782313, and the PPAR-γ rs1801282 polymorphisms in 45-60-year-old women. The study included patients from the general population of the Westpomeranian Province (Poland). The mean age was 54.3 ± 4.2 years. The research procedure involved taking structured history, physical examination, anthropometric measurements, and collecting blood for biochemical and genetic analysis. The patients who met the diagnostic criteria for MetS constituted 38.35% of all participants (sample size: 425 patients). The comparison of blood biochemical parameters revealed numerous differences between the women with MetS and those from the control group. Genetic analysis demonstrated that the T allele of the FTO gene was a factor substantially decreasing the incidence of MetS in the study sample (ORT vs. A = 0.734; 95% CI: 0.555 - 0.970; p < 0.05). Other polymorphisms were not directly related to MetS incidence.