Open AccessEffects of Therapeutic Hypothermia Combined with Other Neuroprotective Strategies on Ischemic Stroke: Review of Evidence
Author(s) -
Zheng Zhang,
Linlei Zhang,
Yuchuan Ding,
Zhao Han,
Xunming Ji
Publication year - 2018
Publication title -
aging and disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.808
H-Index - 54
ISSN - 2152-5250
DOI - 10.14336/ad.2017.0628
Subject(s) - medicine , hypothermia , neuroprotection , stroke (engine) , ischemic stroke , tissue plasminogen activator , food and drug administration , recombinant tissue plasminogen activator , intensive care medicine , drug , therapeutic effect , clinical trial , ischemia , pharmacology , anesthesia , mechanical engineering , modified rankin scale , engineering
Ischemic stroke is a major cause of death and disability globally, and its incidence is increasing. The only treatment approved by the US Food and Drug Administration for acute ischemic stroke is thrombolytic treatment with recombinant tissue plasminogen activator. As an alternative, therapeutic hypothermia has shown excellent potential in preclinical and small clinical studies, but it has largely failed in large clinical studies. This has led clinicians to explore the combination of therapeutic hypothermia with other neuroprotective strategies. This review examines preclinical and clinical progress towards developing highly effective combination therapy involving hypothermia for stroke patients.