Open AccessThe involvement of BDNF, NGF and GDNF in aging and Alzheimer's disease
Author(s) -
Josiane Budni,
Tatiani Bellettini-Santos,
Francielle Mina,
Michelle Lima Garcez,
Alexandra I. Zugno
Publication year - 2015
Publication title -
aging and disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.808
H-Index - 54
ISSN - 2152-5250
DOI - 10.14336/ad.2015.0825
Subject(s) - glial cell line derived neurotrophic factor , neurotrophic factors , nerve growth factor , neuroscience , gdnf family of ligands , neurotrophin , medicine , disease , brain derived neurotrophic factor , brain aging , alzheimer's disease , cognitive decline , cognition , cognitive aging , risk factor , psychology , dementia , receptor
Aging is a normal physiological process accompanied by cognitive decline. This aging process has been the primary risk factor for development of aging-related diseases such as Alzheimer's disease (AD). Cognitive deficit is related to alterations of neurotrophic factors level such as brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF) and glial cell-derived neurotrophic factor (GDNF). These strong relationship between aging and AD is important to investigate the time which they overlap, as well as, the pathophysiological mechanism in each event. Considering that aging and AD are related to cognitive impairment, here we discuss the involving these neurotrophic factors in the aging process and AD.