Open AccessRegulation and Role of TGFβ Signaling Pathway in Aging and Osteoarthritis Joints
Author(s) -
Catherine Baugé
Publication year - 2014
Publication title -
aging and disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.808
H-Index - 54
ISSN - 2152-5250
DOI - 10.14336/ad.2014.0500394
Subject(s) - osteoarthritis , chondrocyte , signal transduction , transforming growth factor , cartilage , transforming growth factor beta , microbiology and biotechnology , medicine , receptor , muscle hypertrophy , cancer research , biology , endocrinology , anatomy , pathology , alternative medicine
Transforming growth factor beta (TGFβ) is a major signalling pathway in joints. This superfamilly is involved in numerous cellular processes in cartilage. Usually, they are considered to favor chondrocyte differentiation and cartilage repair. However, other studies show also deleterious effects of TGFβ which may induce hypertrophy. This may be explained at least in part by alteration of TGFβ signaling pathways in aging chondrocytes. This review focuses on the functions of TGFβ in joints and the regulation of its signaling mediators (receptors, Smads) during aging and osteoarthritis.