Open AccessLifestyle and Advanced Glycation End Products (AGEs) Burden: Its Relevance to Healthy Aging
Author(s) -
Chandan Prasad,
Victorine Imrhan,
Francesco Marotta,
Shanil Juma,
Parakat Vijayagopal
Publication year - 2014
Publication title -
aging and disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.808
H-Index - 54
ISSN - 2152-5250
DOI - 10.14336/ad.2014.0500212
Subject(s) - glycation , medicine , oxidative stress , diabetes mellitus , life style , clinical significance , reactive oxygen species , advanced glycation end product , gerontology , cancer , healthy aging , bioinformatics , physiology , environmental health , endocrinology , biology , biochemistry
Uncontrolled continued exposure to oxidative stress is a precursor to many chronic diseases including cancer, diabetes, degenerative disorders and cardiovascular diseases. Of the many known mediators of oxidative stress, reactive oxygen species (ROS) and advanced glycation end products (AGEs) are the most studied. In the present review, we have summarized current data on the origin of circulating AGEs, discussed issues associated with reliable assessment of its steady state level, and changes in its level with age and select metabolic diseases. Lastly, we have made recommendations about life style changes that may decrease AGEs burden to promote healthy aging.