Open AccessExpression of Prostate-Specific Membrane Antigen in Tumor-Associated Vasculature Predicts Poor Prognosis in Hepatocellular Carcinoma
Author(s) -
Dian Jiao,
Yu Li,
Yang Fa,
Donghui Han,
Jieheng Wu,
Shengjia Shi,
Feng Tian,
Guo Z,
Wenjin Xi,
Guodong Li,
Aizhi Zhao,
An–Gang Yang,
Weijun Qin,
He Wang,
Weihong Wen
Publication year - 2019
Publication title -
clinical and translational gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.673
H-Index - 35
ISSN - 2155-384X
DOI - 10.14309/ctg.0000000000000041
Subject(s) - medicine , glutamate carboxypeptidase ii , immunohistochemistry , prostate cancer , hepatocellular carcinoma , pathology , prostate , pca3 , cancer research , cancer
Prostate-specific membrane antigen (PSMA) was originally found to be specifically expressed in normal prostate, and its expression was upregulated in almost all stages of prostate cancer. In recent years, PSMA was also found to be expressed in tumor-associated vasculature in many nonprostatic solid tumors. However, the expression pattern of PSMA in hepatocellular carcinoma (HCC) is not well studied.