Open AccessUrsodeoxycholic Acid Response Is Associated With Reduced Mortality in Primary Biliary Cholangitis With Compensated Cirrhosis
Author(s) -
Binu John,
Nidah S. Khakoo,
Kaley B Schwartz,
Gabriella Aitchenson,
Cynthia Levy,
Bassam Dahman,
Yangyang Deng,
David S. Goldberg,
Paul Martin,
David Kaplan,
Tamar H. Taddei
Publication year - 2021
Publication title -
the american journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.907
H-Index - 252
eISSN - 1572-0241
pISSN - 0002-9270
DOI - 10.14309/ajg.0000000000001280
Subject(s) - medicine , ursodeoxycholic acid , decompensation , liver transplantation , gastroenterology , hazard ratio , cirrhosis , hepatocellular carcinoma , primary biliary cirrhosis , transplantation , biliary cirrhosis , confidence interval , proportional hazards model , disease , autoimmune disease
Patients with cirrhosis and men have been under-represented in most studies examining the clinical benefit of response to ursodeoxycholic acid (UDCA) in primary biliary cholangitis (PBC). The aim of this study was to study the association of UDCA response and liver-related death or transplantation, hepatic decompensation, and hepatocellular carcinoma (HCC) in patients with PBC cirrhosis.