Open AccessEvidence of Duodenal Epithelial Barrier Impairment and Increased Pyroptosis in Patients With Functional Dyspepsia on Confocal Laser Endomicroscopy and “Ex Vivo” Mucosa Analysis
Author(s) -
Borko Nojkov,
Shi-Yi Zhou,
Russell D. Dolan,
Elisabeth M. Davis,
Henry D. Appelman,
Xueyan Guo,
Kenya Jackson,
Matthew B. Sturm,
Thomas D. Wang,
Chung Owyang,
Julia J. Liu,
William D. Chey
Publication year - 2020
Publication title -
the american journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.907
H-Index - 252
eISSN - 1572-0241
pISSN - 0002-9270
DOI - 10.14309/ajg.0000000000000827
Subject(s) - duodenum , pathology , ex vivo , biopsy , pyroptosis , intestinal mucosa , epithelium , esophagogastroduodenoscopy , medicine , gastroenterology , histology , submucosa , tight junction , inflammation , biology , in vivo , endoscopy , inflammasome , microbiology and biotechnology
Duodenal epithelial barrier impairment and immune activation may play a role in the pathogenesis of functional dyspepsia (FD). This study was aimed to evaluate the duodenal epithelium of patients with FD and healthy individuals for detectable microscopic structural abnormalities.