Open AccessIncreased Risk of COVID-19 Among Users of Proton Pump Inhibitors
Author(s) -
Christopher V. Almario,
William D. Chey,
Brennan Spiegel
Publication year - 2020
Publication title -
the american journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.907
H-Index - 252
eISSN - 1572-0241
pISSN - 0002-9270
DOI - 10.14309/ajg.0000000000000798
Subject(s) - medicine , odds ratio , confounding , logistic regression , confidence interval , covid-19 , proton pump inhibitor , odds , epidemiology , disease , infectious disease (medical specialty)
Proton pump inhibitors (PPIs) increase the risk for enteric infections that is likely related to PPI-induced hypochlorhydria. Although the impact of acid suppression on severe acute respiratory syndrome coronavirus 2 is unknown thus far, previous data revealed that pH ≤3 impairs the infectivity of the similar severe acute respiratory syndrome coronavirus 1. Thus, we aimed to determine whether use of PPIs increases the odds for acquiring coronavirus disease 2019 (COVID-19) among community-dwelling Americans.