Open AccessMast Cell Infiltration Is Associated With Persistent Symptoms and Endoscopic Abnormalities Despite Resolution of Eosinophilia in Pediatric Eosinophilic Esophagitis
Author(s) -
Scott M. Bolton,
Amir F. Kagalwalla,
Nicoleta C. Arva,
Ming Yu Wang,
Katie Amsden,
Héctor Melín-Aldana,
Evan S. Dellon,
Paul J. Bryce,
Barry K. Wershil,
Joshua B. Wechsler
Publication year - 2020
Publication title -
the american journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.907
H-Index - 252
eISSN - 1572-0241
pISSN - 0002-9270
DOI - 10.14309/ajg.0000000000000474
Subject(s) - eosinophilic esophagitis , medicine , eosinophilia , high power field , gastroenterology , eosinophil , odds ratio , endoscopy , proton pump inhibitor , tryptase , esophagitis , esophagus , mast cell , pathology , asthma , immunohistochemistry , disease , reflux , immunology
Mast cells (MCs) are increased in eosinophilic esophagitis (EoE). Endoscopic abnormalities, symptoms, and epithelial changes can persist after treatment despite a reduction of esophageal eosinophilia. It is unknown whether this could be due to persistent MC infiltration. We aimed to determine whether patients with histologically inactive (HI) EoE (defined as <15 eosinophils per high-powered field) with persistent symptoms, endoscopic, or epithelial abnormalities after treatment have increased MCs.