Open AccessPhase Transition Is Infrequent Among North American Adults With e-Antigen-Negative Chronic Hepatitis B and Low-Level Viremia
Author(s) -
Kali Zhou,
Abdus S. Wahed,
Stewart Cooper,
Adrian M. Di Bisceglie,
Robert J. Fontana,
Marc G. Ghany,
Mandana Khalili,
Anna S. Lok,
Robert P. Perrillo,
William M. Lee,
Daryl Lau,
Richard K. Sterling,
Harry L.A. Janssen,
Norah Terrault
Publication year - 2019
Publication title -
the american journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.907
H-Index - 252
eISSN - 1572-0241
pISSN - 0002-9270
DOI - 10.14309/ajg.0000000000000400
Subject(s) - medicine , viremia , hbeag , hepatitis b virus , gastroenterology , hepatitis b , cohort , viral load , hepatology , incidence (geometry) , immunology , proportional hazards model , hbsag , virus , physics , optics
Patients with hepatitis B early antigen (HBeAg)-negative chronic hepatitis B (CHB) and low-level viremia are a heterogeneous group. Identifying those at risk of developing active CHB requiring antiviral therapy is important. In this study, we prospectively characterize incidence rates and predictors of transitioning from inactive to active CHB in a North American adult cohort.