Open AccessOne-Hour Esophageal String Test: A Nonendoscopic Minimally Invasive Test That Accurately Detects Disease Activity in Eosinophilic Esophagitis
Author(s) -
Steven J. Ackerman,
Amir F. Kagalwalla,
Ikuo Hirano,
Nirmala Gonsalves,
Paul Menard Katcher,
Sandeep K. Gupta,
Joshua B. Wechsler,
Milica Grozdanović,
Zhaoxing Pan,
Joanne C. Masterson,
Jian Du,
Robert J. Fantus,
Preeth Alumkal,
James J. Lee,
Sergei I. Ochkur,
Faria Ahmed,
Kelley E. Capocelli,
Héctor Melín-Aldana,
Kathryn A. Biette,
Allison Dubner,
Katie Amsden,
Kaitlin Keeley,
Maureen Sulkowski,
Angelika Zalewski,
Dan Atkins,
Glenn T. Furuta
Publication year - 2019
Publication title -
the american journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.907
H-Index - 252
eISSN - 1572-0241
pISSN - 0002-9270
DOI - 10.14309/ajg.0000000000000371
Subject(s) - eosinophilic esophagitis , medicine , esophagogastroduodenoscopy , eosinophil , esophagus , gastroenterology , biopsy , high power field , esophageal disease , major basic protein , dysphagia , endoscopy , disease , pathology , asthma , surgery , immunohistochemistry
Eosinophilic esophagitis (EoE), a chronic food allergic disease, lacks sensitive and specific peripheral biomarkers. We hypothesized that levels of EoE-related biomarkers captured using a 1-hour minimally invasive Esophageal String Test (EST) would correlate with mucosal eosinophil counts and tissue concentrations of these same biomarkers. We aimed to determine whether a 1-hour EST accurately distinguishes active from inactive EoE or a normal esophagus.