Evaluation of Memantine in AAV-AD Rat: A Model of Late-Onset Alzheimer’s Disease Predementia | Zendy

Benoît Souchet | Zendy; Mickaël Audrain | Zendy; Sandro Alves | Zendy; Romain Fol | Zendy; Satoru Tada | Zendy; Nicola Salvatore Orefice | Zendy; Brigitte Potier | Zendy; P. Dutar | Zendy; JeanMarie Billard | Zendy; Nathalie Cartier | Zendy; Jérôme Braudeau | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Evaluation of Memantine in AAV-AD Rat: A Model of Late-Onset Alzheimer’s Disease Predementia

Author(s) -

Benoît Souchet,

Mickaël Audrain,

Sandro Alves,

Romain Fol,

Satoru Tada,

Nicola Salvatore Orefice,

Brigitte Potier,

P. Dutar,

JeanMarie Billard,

Nathalie Cartier,

Jérôme Braudeau

Publication year - 2021

Publication title -

the journal of prevention of alzheimer s disease

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.733

H-Index - 13

eISSN - 2426-0266

pISSN - 2274-5807

DOI - 10.14283/jpad.2021.67

Subject(s) - memantine , tauopathy , disease , asymptomatic , dementia , medicine , pathological , alzheimer's disease , cognitive decline , neuroscience , psychology , pharmacology , neurodegeneration

Though our understanding of Alzheimer's disease (AD) remains elusive, it is well known that the disease starts long before the first signs of dementia. This is supported by the large number of symptomatic drug failures in clinical trials and the increased trend to enroll patients at predementia stages with either mild or no cognitive symptoms. However, the design of pre-clinical studies does not follow this attitude, in particular regarding the choice of animal models, often irrelevant to mimic predementia Late Onset Alzheimer's Disease (LOAD).

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research