Open AccessRELATIONSHIP BETWEEN GRIP STRENGTH AND NONALCOHOLIC FATTY LIVER DISEASE IN MEN LIVING WITH HIV REFERRED TO A METABOLIC CLINIC
Author(s) -
Paula Debroy,
Jordan E. Lake,
Andrea Malagoli,
Giovanni Guaraldi
Publication year - 2018
Publication title -
the journal of frailty and aging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.786
H-Index - 17
eISSN - 2273-4309
pISSN - 2260-1341
DOI - 10.14283/jfa.2018.37
Subject(s) - medicine , nonalcoholic fatty liver disease , sarcopenia , grip strength , gastroenterology , logistic regression , liver disease , body mass index , human immunodeficiency virus (hiv) , fatty liver , disease , physical therapy , immunology
This study aimed to assess the relationship between grip strength (GS) and nonalcoholic fatty liver (NAFLD) in treated HIV-infected men. We included 169 HIV-infected men. GS was assessed using a hand-grip dynamometer. NALFD was defined by liver-spleen attenuation ratio <1.1 on computed tomography. Mean (SD) age was 57 (6) years and BMI 24.5 (2.9) kg/m2. NAFLD was diagnosed in 33% of men; sarcopenia was present in 28%. Mean (SD) hand grip strength in the dominant hand was 37.5 (7.6) kg. In multivariate logistic regression, intermediate and low GS were associated with higher risk of NAFLD (OR 3.05; CI 1.27-7.61, p=0.01; OR 2.47; CI 1.01-6.19, p=0.05, respectively). GS has an inverse association with NAFLD prevalence in HIV-infected men. Specific mechanisms through which muscle weakness and NAFLD are related require further exploration but are not accounted for merely by the burden of comorbid illness, HIV disease stage, or ART exposure.