Open AccessStudy of Liver Function Test in COVID-19 Patients and Its Correlation with Inflammatory Markers from Hubballi, Karnataka
Author(s) -
Kalinga Bommanakatti Eranaik,
Uday Subhash Bande,
L.M. Veeresh
Publication year - 2021
Publication title -
journal of evolution of medical and dental sciences
Language(s) - English
Resource type - Journals
eISSN - 2278-4802
pISSN - 2278-4748
DOI - 10.14260/jemds/2021/795
Subject(s) - medicine , liver function tests , alanine transaminase , aspartate transaminase , gastroenterology , liver function , liver injury , lactate dehydrogenase , liver disease , transaminase , prospective cohort study , ferritin , gamma glutamyltransferase , enzyme , alkaline phosphatase , biochemistry , chemistry
BACKGROUND Since its reporting in December 2019, SARC-COV-2 (COVID -19) has infected more than 230 million people over the world by colonising the respiratory tract, however very little is known about its effect on liver and how the liver injury affects disease prognosis. This study was done to assess the hepatic profile in SARC-COV-2 infection along with inflammatory markers. METHODS This is a single centred prospective observational study. 400 patients with real time polymerase chain reaction (PCR) confirmed COVID 19 infection admitted in KIMS, Hubballi were taken for study. Patients with decompensated liver disease were excluded from the study. Clinical examination and laboratory investigations including liver function test (LFT), renal function test (RFT), complete blood count (CBC), chest X-ray, D-dimer, ferritin, lactate dehydrogenase (LDH), C reactive protein (CRP) was done for all the patients. RESULTS Out of the 400 covid-19 positive patients admitted, 286 (71.5 %) had abnormal liver enzymes. Significantly raised liver enzymes were seen in males. Raised liver enzymes and inflammatory markers were associated with poor outcome of the disease. Significant reduced albumin was associated with poor outcome of the disease. Significantly raised aspartate transaminase (AST), alanine transaminase (ALT) levels were associated with increased severity of the disease. (P = 0.009 and 0.029 respectively). Significant positive relation was found between liver profile and inflammatory markers. CONCLUSIONS Majority of patients admitted with SARS-CoV-2 had deranged liver profile. Higher proportion of abnormal liver enzymes were seen in males. Degree of liver injury increases with increasing severity of the disease. Even though abnormal liver enzymes were positively associated with elevated inflammatory markers and severity of the disease, more studies are needed to study implications of liver injury in prognosis of SARS-CoV-2 infection. KEY WORDS Liver Function Test, SARS-CoV-2 Infection. Hepatocellular Injury, Cholestatic Injury, Inflammatory Markers