Open AccessMorbidities Related to Obesity- A Short Review of Literature
Author(s) -
Lata Kanyal Butola,
Deepika Kanyal,
Archana Dhok
Publication year - 2021
Publication title -
journal of evolution of medical and dental sciences
Language(s) - English
Resource type - Journals
eISSN - 2278-4802
pISSN - 2278-4748
DOI - 10.14260/jemds/2021/753
Subject(s) - medicine , obesity , dyslipidemia , diabetes mellitus , insulin resistance , adipokine , type 2 diabetes , adipose tissue , type 2 diabetes mellitus , oxidative stress , pathogenesis , risk factor , metabolic syndrome , coronary artery disease , endocrinology
Obesity is a significant risk factor for cardiovascular disorders, metabolic disorders, osteoarthritis, multiple cancers, serious mental illness, hypertension, dyslipidemia, diabetes mellitus and coronary artery disease. Obesity has been reported to promote oxidative stress, as obesity stimulates the penetration and activation of macrophages and monocytes into adipose tissue which, in turn, releases elevated levels of pro-inflammatory adipokines, such as tumour necrosis factor-alpha ( TNFa) and interleukin-6 (IL-6).Insulin resistance is associated with both type 2 diabetes and obesity. Alteration of lung mechanics in obese patients, including decreased lung capacities, decreased compliance, irregular breathing and perfusion and gas exchange, and respiratory muscle inefficiency, can predispose to increased risk and severity of respiratory infections. Obesity and atherosclerosis pathogenesis have many popular causes. In all cases, lipids, oxidized LDL particles and free fatty acids trigger the inflammatory response and induce the disease. In this review article, we have focused on different morbidities related to obesity. KEYWORDS Obesity, Diabetes Mellitus, Hypertension, Oxidative Stress, Osteoarthritis