Open AccessCLINICAL PROFILE OF ANAEMIA AMONG HIV INFECTED PATIENTS AND ITS CORRELATION WITH CD4+ COUNT
Author(s) -
Neetha Santosh,
Velho G. Rachita,
Sindhoora Kotha,
Cacodcar Jagadish
Publication year - 2015
Publication title -
journal of evolution of medical and dental sciences
Language(s) - English
Resource type - Journals
eISSN - 2278-4802
pISSN - 2278-4748
DOI - 10.14260/jemds/2015/1558
Subject(s) - medicine , human immunodeficiency virus (hiv) , correlation , virology , mathematics , geometry
BACKGROUND: Various haematological manifestations are seen in HIV patients ranging from anaemia, thrombocytopenia, leucopenia, coagulation abnormalities and malignancies. Anaemia is recognized to be a significant clinical problem in patients with HIV infection and AIDS. Although anaemia can occur at any stage of HIV infection, its frequency and severity are positively correlated with progression of the disease. Anaemia appears to be independently associated with decreased survival in patients with HIV infection and AIDS. AIMS AND OBJECTIVES: to study the clinical profile of anaemia in HIV patients and to know its correlation with the CD4 count. RESULTS: Of the 43 patients studied, 34 were on HAART and 9 were treatment naïve subjects. Severe anaemia was detected in 23 subjects, moderate anaemia in 16 and mild anaemia was seen in 4 subjects. The mean haemoglobin of the study population was 7.57gm%. 16 of the anaemic individuals had CD4+ count <200 cells/mm3. 21 patients (48.83%) had Zidovudine induced anaemia, 11 patients (25.58%) had anaemia of chronic disease, 8 patients (18.60%) had iron deficiency anaemia, 2 patients (4.65%) had both Zidovudine induced and iron deficiency anaemia and 1 patient (2.3%) had megaloblastic anaemia. CONCLUSIONS: Severity of anaemia significantly correlated with the CD4+ count in this study. Zidovudine induced anaemia was the most common type of anaemia, with a prevalence of 48.83%. Bone marrow was found to be normocellular in 67.5% of the study population and had no correlation with CD4+ count.