Open AccessDEVELOPMENT OF TECHNOLOGY FOR PRODUCTION OF SUBSTANCE SILECBINE ON THE BASIS OF EC-DYSTEROIDS OF THE AERIAL PARTS OF SILENE BRAHUICA
Author(s) -
Халилов Равшанжон Муратджанович,
Якубова Мохира Рахимовна
Publication year - 2021
Publication title -
himiâ rastitelʹnogo syrʹâ
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.2
H-Index - 6
eISSN - 1029-5151
pISSN - 1029-5143
DOI - 10.14258/jcprm.2021039119
Subject(s) - extraction (chemistry) , chromatography , chemistry , silene , microcrystalline cellulose , ecdysterone , raw material , cellulose , organic chemistry , botany , biochemistry , hormone , biology
The process extraction of ecdysterone from the aerial parts of Silene brahuica was studied. On the basis results research, the following extraction conditions were established: extractant – 90% ethanol, particle size of raw material – no more than 5 mm and process temperature – 20–30 °C. A five-fold extraction of ecdysterone from the aerial parts of Silene brahuica is proposed. To purify of the extract, a sequential liquid-liquid extraction is proposed, according to which the concentrated extract is diluted with water and treated three times with extraction petrol to remove hydrophobic impurities, then extracted six times with butanol to remove hydrophilic impurities. For effective drying of the silekbin substance, a filler was used, as which microcrystalline cellulose was selected in a mass ratio of 1 : 2 to the dry residue of the dried water solution. The technology of obtaining the substance of the adaptogenic and immunostimulating drug "Silekbin" from the aerial parts of Silene brahuica, which is tested on semi-industrial installations of the Pilot production of the Institute of the Chemistry of Plant Substances, has been developed.