Open AccessTRITERPENE GLYCOSIDE FROM THE PLANT CORTUSA MATTHIOLI L.
Author(s) -
Igor' Vasil'yevich Beshley,
Т. И. Ширшова,
В. В. Володин,
Kirill Gennad'yevich Ufimtsev,
N. G. Kolotyrkina,
И. Н. Алексеев,
S. A. Patov
Publication year - 2019
Publication title -
himiâ rastitelʹnogo syrʹâ
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.2
H-Index - 6
eISSN - 1029-5151
pISSN - 1029-5143
DOI - 10.14258/jcprm.2019045133
Subject(s) - triterpene , glycoside , primulaceae , botany , biology , stereochemistry , genus , chemistry , traditional medicine , medicine , alternative medicine , pathology
Some representatives of the Primulaceae family consider to a promising sources of saponins. It is established that some species of this family contain significant concentrations of triterpene glycosides having interesting biological. According to the literature, in plants Cortusa turkestanica Losinsk. both steroid and triterpene glycosides were found, the content of which is 7.3%, and the hemolytic index reaches 25.000. The only representative of the genus Cortusa in the flora of the Komi Republic is Cortusa matthioli L. It is a boreal Eurasian species that grows almost everywhere in the forest zone of the Republic. From the aboveground part of the plant C. mattioli, collected in the vicinity of Syktyvkar in the flowering phase, by we for the first time were isolated triterpene glycoside pentacyclic series with gross formula C52H84O22. Using spectral methods (IR, NMR spectroscopy and high resolution mass spectrometry), the compound was identified as β-D-xylopyranosyl-(1→2)-β-D-glucopyranosyl-(1→4)-[β-D-glucopyranosyl-(1→2)]-α-L-arabinopyranosyl-(1→3)-13β, 28-epoxyolean-30-al-3β, 16α-diol. Previously this compound, for which cytotoxic activity against human colon cancer cells, uterine sarcoma and human melanoma was detected, was found in plants of Ardisia crispa, Myrsine pellucida, Androsace saxifragifolia, as well as some species of the genus Cyclamen.