Open AccessINVESTIGATION OF FLAVONOIDS OF THE ROOT OF THE PLANT SCUTELLARIA INTERMEDIA POPOV
Author(s) -
А. М. Каримов,
Антон Сергеевич Попков,
Юлия Владимировна Остроушко,
Румия Исаевна Туртаева,
Э. Х. Ботиров
Publication year - 2018
Publication title -
himiâ rastitelʹnogo syrʹâ
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.2
H-Index - 6
eISSN - 1029-5151
pISSN - 1029-5143
DOI - 10.14258/jcprm.2018043728
Subject(s) - scutellaria , lamiaceae , traditional medicine , phytochemical , scutellaria baicalensis , chemistry , ethyl acetate , botany , folk medicine , stereochemistry , biology , organic chemistry , traditional chinese medicine , medicine , alternative medicine , pathology
Plants of the genus Scutellaria L. – the skullcap (the Lamiaceae family) on the globe are represented by 360 species, widespread in temperate, subtropical and tropical regions, including Europe, North America and East Asia. They are used in folk medicine and are a source of unique biologically active compounds with valuable pharmacological properties. The article is devoted to the phytochemical study of the flavonoids of the roots of S. intermedia. From the ethyl acetate and n-butanol fractions of the 80% ethanol extract of the roots, 6 flavonoids were first isolated. Based on the results of chemical transformations, UV, 1H, 13C NMR and mass spectra, comparison of physicochemical constants with literature data, and comparison with samples of flavonoids isolated from other species of Scutellaria L., the compounds obtained wogonine, 5,8-dihydroxy-7-methoxyflavone, 5,7,4'-trihydroxy-6-methoxyflavanone (dihydrohispidulin) 5,6,7,4'-tetrahydro- xiflavane (dihydroscutellarein), luteoline and baicalein 7-O-β-D-ethyl glucuronide.