Open AccessRelation of bleeding patterns and factor VIII levels in children with hemophilia
Author(s) -
Rina Rahardiani,
Hydrie Mz,
Agus Firmansyah
Publication year - 2016
Publication title -
paediatrica indonesiana
Language(s) - English
Resource type - Journals
eISSN - 2338-476X
pISSN - 0030-9311
DOI - 10.14238/pi46.4.2006.159-63
Subject(s) - medicine , cryoprecipitate , bleed , pediatrics , family history , severe bleeding , retrospective cohort study , uterine bleeding , surgery , fibrinogen
Background The high costs of factor VIII examination cause thedelay in the diagnosis of hemophilia A; consequently many pa-tients do not receive adequate therapy which results in failure tosurvive into adulthood or survive with creeple.Objective To determine bleeding patterns of hemophilia A pa-tients for the prediction of its classification.Methods We perform retrospective analysis of hemophilia patientsat the Integrated Service Center of Hemophilia, Cipto Mangun-kusumo Hospital, Jakarta.Results Family history, age at the first bleeding, frequency of bleed-ing, and factor VIII examination can significantly differentiate theclassification of hemophilia A (P=0.015; 0.014; <0.0001; and<0.0001, respectively) while age groups, triggering trauma for thefirst bleeding, type of the first bleeding, history of previous trauma,the most frequent type of bleeding, age at diagnosis, and con-sumption of cryoprecipitate cannot. (P=0.985; 0.475; 0.342; 0.318;0.058; 0.477; and 0.547, respectively).Conclusion Age at first bleeding, frequency of bleeding, and fam-ily history can be used to predict classification of hemophilia A.